Differences in amino acid composition of carrot α-tubulin potentially confer the resistance to dinitroaniline herbicides

Aim. To reveal the features of amino acid composition carrot α-tubulin isotypes that potentially determine natural tolerance to dinitroaniline herbicides. Methods. Literature and database search. Comparison protein sequences structures: multiple sequence alignment, phylogenetic profiling, ligand structure modeling, etc. Results. Genomic proteomic analysis Daucus carota has revealed at least eight unique differ in gene loci. Remarkable differences dinitroanilinebinding-like (DBL) region analyzed have been revealed, which may be reason its resistance these compounds. Сonclusions. Differences acids positions canonical mutations – Cys4 (TBA1, 2, 3, 6, 7 8), Thr53 (TBA6), Ile202 (TBA1 7) Met202 (TBA5), as well previously undescribed non-canonical substitutions Ile4 (TBA4 5), Cys52 Ser201 3 8) Val194 were noted associated with